Research
Projects, 2008
Project
|
Location
|
Principal Investigator
|
Status |
|
1.
Anesthesia residents training in fiberoptic intubation –new
technique: a) Double fiberoptic technique for
intubation b) Retrograde-assisted fiberoptic intubation
through tube exchanger used as spacer |
SUNY Downstate |
Apostol, A |
Active |
|
2.Magnesium
+ Obstetric Patients: a)
Brain bioavailability of peripherally
administered magnesium sulfate in preeclamptic
patients b)
Association between the length of
prenatal exposure of preterm newborns to magnesium sulfate and
neural development outcome during the fist year of life |
SUNY Downstate |
Apostol, A/ Altura, B (Dept of Physiology)
alexandru.apostol@downstate.edu
|
Active |
|
3.
Intra-cerebral hemodynamic monitoring in pregnant patients
during Cesarean section under spinal-epidural anesthesia |
SUNY Downstate |
Apostol, A |
IRB Approval Pending |
|
4.
Dexmedetomidine infusion for lumbar spine surgery |
SUNY Downstate |
Bendo, A
audree.bendo@downstate.edu |
IRB Approved |
|
5.
Case Series 1.
Effect of dexmedetomidine on postop pain
in patients undergoing spine surgery 2.
Effect of dexmedetomidine IV infusion
during MAC cases for spinal cord stimulation in drug-dependent
cases. |
SUNY Downstate |
Bendo, A |
Active |
|
6.
Correlation of complement activation and factors with delayed
cerebral vasospasm and delayed ischemic neurological deficits in
aneurysmal subarachnoid hemorrhage patients |
SUNY Downstate |
Bendo, A/ Zhang, M |
IRB Approval Pending |
|
7.
Multi-center, continuous, peripheral nerve block surveillance
study comparing ultrasound-guided catheter placement to
non-ultrasound-guided catheter placement techniques |
SUNY Downstate Lutheran Medical Center |
Coloma, K/Dimaculangan, D |
IRB Approval Pending |
|
8.
The relationship of depth of
anesthesia to remote postop cognitive dysfunction |
SUNY Downstate |
Cottrell, JE/ Twersky, RS |
|
|
9. Awareness and recall under
anesthesia in major trauma patients. |
KCHC |
Charchaflieh, J/deLong, L |
Proposal in Development |
|
10.
Temporal alterations in complement
expression profiles are associated with increased
mortality in septic shock |
SUNY Downstate |
Charchaflieh, J/ Zhang, M/ Stutz, H |
IRB Approved |
|
11.
A randomized, controlled, phase 3 study of gentamicin-collagen
sponge (Collagen G) in general surgical subjects at higher risk
for surgical wound infection (Innocoll Co.) |
SUNY Downstate |
Charchaflieh, J/ Zhang, M/ Kim, S (Dept of
Surgery) |
IRB Approval Pending |
|
12.
Efficacy and safety of drotrecogin alfa (activated) in adult
patients with septic shock (Eli Lilly and Company) |
SUNY Downstate |
Charchaflieh, J/Zhang, M/ Stutz H |
IRB Approval Pending |
|
13.
The effect of a periarticular injection
of bupivacaine- ketorolac-epinephrine- morphine-mixture, in
addition to a continuous femoral nerve block, on rehabilitation
and postop pain in patients undergoing total knee replacement. |
SUNY Downstate |
Dimaculangan, D |
IRB Approved |
|
14.
Study comparing the effects of PCEA vs.
periarticular singleshot injection (SSI) vs. continuous
periarticular infiltration (CPI) of local anesthetic, on top of
a standard multimodal postop pain management strategy, on pain
and rehabilitation outcomes in patients undergoing total hip
replacement surgery |
SUNY Downstate |
Dimaculangan, D |
IRB Approval Pending |
|
15.
Retrospective chart review to determine pain and rehabilitation
outcomes in patients receiving multimodal analgesic regimen for
total knee replacement surgery 2003-2006. |
SUNY Downstate |
Dimaculangan, D |
Active |
|
16.
Learning curve for the utilization of ultrasound during regional
anesthesia/line: a) Learning curve for brachial plexus ultrasound
imaging by anesthesia residents using the Cusum method |
SUNY Downstate |
Dimaculangan, D |
IRB Approval Pending |
|
17.
Case Series: Anesthesia management for total hip
replacement in sickle cell cases – Report on3 patients |
SUNY Downstate |
Dimaculangan, D/ Gillette, P (Dept of
Hematology/Oncology |
Active |
|
18.
Observational study evaluating compliance with pain management
regimen using urine toxicology |
KCHC |
Ganesan, S |
Protocol in Development |
|
19.
Airway management manual and basic workshop (for CA1
residents) |
SUNY Downstate LICH |
Lazar, C |
Active |
|
20.
Postop monitoring, respiratory outcomes and airway complications
in transport and in PACU. |
LICH |
Lokhandwala, B |
Active |
|
21.
Evaluating phantom limb pain with neuraxial anesthesia |
SUNY Downstate LICH |
Reyfman, L |
Protocol in Development |
|
22.
Retrospective review of outcomes of patients with loose teeth |
SUNY Downstate KCHC, Lutheran Medical Center, LICH |
Sharma, N |
Proposal in Development |
|
23.
Innate immunity responses to ischemic changes during
cardiac surgery. |
SUNY Downstate |
Shevde, K/ Zhang, M |
Active |
|
24.
Dexmedetomidine infusion in cardiac surgery patients: a
randomized, prospective, double-blind study to test the renal
benefits and myocardial protection. |
SUNY Downstate |
Shevde, K |
IRB Approval Pending |
|
25.
Preservation of neurological and cognitive function utilizing
high-dose midazolam in cardiac surgery patients |
SUNY Downstate |
Shevde, K/ Cottrell JE/Kass I |
Protocol in Development |
|
26.
Do different positioning techniques benefit access to
intervertebral space during spinal and epidural neuraxial
anesthesia? |
SUNY Downstate |
Shevde, K/Dimaculangan, D |
Protocol in Development |
|
27.
ACEI/ARB in ambulatory and day-of-surgery patients |
LICH |
Twersky, RS |
Active |
|
28.
A randomized, multiple-center, double-blind, placebo-controlled
study of the safety and analgesic efficacy of repeated dosing of
PMI-150 (intranasal Ketamine) to treat acute post-operative pain
following orthopedic trauma, injury or surgery (Javelin
Pharmaceuticals) |
SUNY Downstate Lutheran Medical Center |
Twersky, RS/ Wagner, L / Dimaculangan, D |
IRB Approval Pending |
|
29.
Anesthetic management of patients with peripartum cardiomyopathy |
SUNY Downstate |
Velickovic, I |
Proposal in Development |
|
30.
Relationship between lactic acid levels and pre-eclampsia |
Lutheran Medical Center |
Zaratzian, A |
IRB Approval Pending |
|
BASIC SCIENCE |
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|
31.
Amnesic agents and PKMzeta |
SUNY Downstate |
Cottrell, JE/ Sacktor, T (Dept of Physiology,
Pharmacology and Neurology) |
Protocol in Development |
|
32.
Desflurane preconditioning study using the rat hippocampal slice
model. |
SUNY Downstate |
Dimaculangan, D |
Active (Preparing set-up in Physiology Lab) |
|
33.
Effects of anesthetics on acid-sensing ion channels (ASICs)
(Legacy Research Lab – Dr Zhigang Xiong) |
Legacy Research Lab - Portland, Oregon |
Lin, J |
Active |
|
34.
Middle cerebral artery occlusion: examine mechanisms by which
low anti-arrhythmic doses of lidocaine and clinical doses of
other anesthetic agents effect focal cerebral ischemia. |
SUNY Downstate |
Popp, S/Cottrell, JE (Dr Kass’ Lab) |
Active |
|
35.
Global cerebral ischemia: examine the effect of lidocaine and
sevoflurane preconditioning on histology, immunocytochemistry
and behavior following global cerebral ischemia |
SUNY Downstate |
Cottrell JE (Dr Kass’ Lab) |
Active |
|
36.
Acute brain slice: mechanisms by which anesthetics reduce
hypoxic neuronal damage – to examine the effects of anesthesia
on electrophysiological, molecular biological and
biochemical parameters before, during and after hypoxia |
SUNY Downstate |
Wang, J/ Meng F/Cottrell JE |
Active |
|
37.
The effect of antiarrhythmics on hypoxic neuronal damage in rat
hippocampal slices. |
SUNY Downstate |
Worah, S |
Active |
|
38.
Animal models of ischemia and sepsis: to examine the innate
immune responses to ischemia in genetically-modified
animals |
SUNY Downstate |
Zhang, M/ Kass, I/ Charchaflieh, J |
Active |
|
39.
MEMS umbrella-shaped actuator with active structure for medical
applications |
SUNY Downstate |
Zhang, M / Mangla, S (Dept of Interventional
Radiology )
ming.zhang@downstate.edu |
Protocol in Development |
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